Which statement best describes the cardiometabolic risk associated with NAFLD?

Which statement best describes the cardiometabolic risk associated with NAFLD?

• A. Decreased risk of cardiovascular disease
• B. No effect on cardiovascular risk
• C. Only affects mood
• D. Increased cardiovascular disease risk

Answer: (D)

NAFLD is tied to a cluster of metabolic abnormalities that elevate cardiovascular disease risk. Liver fat accumulation often accompanies insulin resistance, higher triglycerides and lower HDL, hypertension, and obesity. These factors promote atherogenesis and vascular dysfunction, so NAFLD signals an increased likelihood of cardiovascular events beyond what you’d expect from the liver alone. That’s why stating that cardiovascular disease risk is increased best describes the cardiometabolic impact of NAFLD. The other options overlook the well-established link between NAFLD and cardiovascular risk, either implying protection, no effect, or a mood-related effect, which doesn’t fit the evidence. Managing NAFLD typically involves improving metabolic health through weight loss, physical activity, and control of glucose, lipids, and blood pressure to reduce both liver and cardiovascular risk.

NAFLD is tied to a cluster of metabolic abnormalities that elevate cardiovascular disease risk. Liver fat accumulation often accompanies insulin resistance, higher triglycerides and lower HDL, hypertension, and obesity. These factors promote atherogenesis and vascular dysfunction, so NAFLD signals an increased likelihood of cardiovascular events beyond what you’d expect from the liver alone. That’s why stating that cardiovascular disease risk is increased best describes the cardiometabolic impact of NAFLD. The other options overlook the well-established link between NAFLD and cardiovascular risk, either implying protection, no effect, or a mood-related effect, which doesn’t fit the evidence. Managing NAFLD typically involves improving metabolic health through weight loss, physical activity, and control of glucose, lipids, and blood pressure to reduce both liver and cardiovascular risk.