Which statement accurately characterizes GLP-1 receptor agonists?

Which statement accurately characterizes GLP-1 receptor agonists?

• A. They are exemplified by Exenatide and Dulaglutide
• B. They are not used clinically
• C. They inhibit SGLT2
• D. They increase gastric emptying

Answer: (A)

GLP-1 receptor agonists mimic the incretin GLP-1 and are used clinically to improve blood sugar control in type 2 diabetes (and can aid weight loss in some patients). They work by increasing insulin secretion in a glucose-dependent manner, suppressing glucagon, and slowing gastric emptying, which helps blunt postprandial glucose spikes and promotes satiety. Exenatide and Dulaglutide are classic examples of this drug class, so stating that they exemplify GLP-1 receptor agonists is correct. They do not inhibit SGLT2 (that’s a separate class of drugs) and they do not increase gastric emptying; they slow it.

GLP-1 receptor agonists mimic the incretin GLP-1 and are used clinically to improve blood sugar control in type 2 diabetes (and can aid weight loss in some patients). They work by increasing insulin secretion in a glucose-dependent manner, suppressing glucagon, and slowing gastric emptying, which helps blunt postprandial glucose spikes and promotes satiety. Exenatide and Dulaglutide are classic examples of this drug class, so stating that they exemplify GLP-1 receptor agonists is correct. They do not inhibit SGLT2 (that’s a separate class of drugs) and they do not increase gastric emptying; they slow it.