Which is an example of an amylin analogue?

Which is an example of an amylin analogue?

• A. Pramlintide
• B. Exenatide
• C. Canagliflozin
• D. Metformin

Answer: (A)

Amylin analogues mimic the hormone amylin, which is released with insulin and helps regulate post-meal glucose by slowing gastric emptying, suppressing glucagon, and promoting satiety. Pramlintide is a synthetic analogue of amylin and is used as an adjunct to mealtime insulin to blunt postprandial glucose spikes. The other options act through different mechanisms—Exenatide is a GLP-1 receptor agonist, Canagliflozin is an SGLT2 inhibitor, and Metformin reduces hepatic glucose production and improves insulin sensitivity—so they are not amylin analogues.

Amylin analogues mimic the hormone amylin, which is released with insulin and helps regulate post-meal glucose by slowing gastric emptying, suppressing glucagon, and promoting satiety. Pramlintide is a synthetic analogue of amylin and is used as an adjunct to mealtime insulin to blunt postprandial glucose spikes. The other options act through different mechanisms—Exenatide is a GLP-1 receptor agonist, Canagliflozin is an SGLT2 inhibitor, and Metformin reduces hepatic glucose production and improves insulin sensitivity—so they are not amylin analogues.