ARB therapy is particularly used when ACE inhibitors are not tolerated.

ARB therapy is particularly used when ACE inhibitors are not tolerated.

• A. ARBs
• B. Beta blockers
• C. Calcium channel blockers
• D. Diuretics

Answer: (A)

ARB therapy is used when ACE inhibitors are not tolerated because ARBs block the angiotensin II receptor, giving the same blood pressure and organ-protective effects as ACE inhibitors without increasing bradykinin. That means the common ACE-inhibitor side effects like cough and angioedema are much less likely with ARBs, making them the preferred alternative in patients who can’t take ACE inhibitors. Other drug classes listed work through different mechanisms (beta blockers affect heart rate and contractility, calcium channel blockers relax vessels by a different pathway, diuretics reduce fluid volume), so they don’t specifically replace ACE inhibitors for renin-angiotensin system blockade when intolerance is the issue.

ARB therapy is used when ACE inhibitors are not tolerated because ARBs block the angiotensin II receptor, giving the same blood pressure and organ-protective effects as ACE inhibitors without increasing bradykinin. That means the common ACE-inhibitor side effects like cough and angioedema are much less likely with ARBs, making them the preferred alternative in patients who can’t take ACE inhibitors. Other drug classes listed work through different mechanisms (beta blockers affect heart rate and contractility, calcium channel blockers relax vessels by a different pathway, diuretics reduce fluid volume), so they don’t specifically replace ACE inhibitors for renin-angiotensin system blockade when intolerance is the issue.